Study Published in Wounds Journal Shows Remarkable Wound Closure Performance with CollPlant’s VergenixFG in the Treatment of Chronic Wounds with a 94% Median Wound Area Reduction within 4-weeks
Ness Ziona, Israel, March 11, 2019 -- CollPlant (Nasdaq: CLGN), a regenerative medicine company, today announced results from a clinical study conducted with its VergenixFG wound care product. The results were published in Wounds, a peer-reviewed journal focusing on wound care and wound research. The paper titled, “A Novel Recombinant Human Collagen-based Flowable Matrix for Chronic Lower Limb Wound Management: First Results of a Clinical Trial,” presents data from a previously reported independent study conducted by physicians at several wound care medical clinics and hospitals in Israel.
The advanced wound care treatment market was estimated at $8.2 billion in 2017, with non-healing chronic ulcers posing a significant health concern and economic burden. While animal-derived collagens have been used to treat chronic wounds, they fail to closely mimic the function of human collagen, and can evoke immune response, as well as carry the risk of disease transmission.
VergenixFG is a unique flowable wound-filler of truly human collagen derived from genetically engineered plants using CollPlant’s proprietary process. Consequently, VergenixFG accelerates the healing of chronic and acute wounds.
In the published study, twenty patients with chronic lower limb ulcers were enrolled in a single-arm, open-label, multicenter trial through five treatment centers. Patients underwent a single treatment with CollPlant’s VergenixFG. Four weeks following treatment, nine wounds closed completely, fifteen wounds exhibited a greater than 70% closure, and the median wound area reduction was 94%. Only one patient failed to respond to treatment. All patients in the study reported a 50% reduction in pain.
Yehiel Tal, CEO of CollPlant stated, "This study, conducted by an independent group of physicians, demonstrates that a single application of VergenixFG yields remarkable wound closure results. Furthermore, comparing this study to other published studies conducted with animal-derived collagens reveals that VergenixFG is more potent. VergenixFG is commercially available in Europe, and we are expanding our market presence to other markets.”
CollPlant is a regenerative medicine company focused on 3D bioprinting of tissues and organs, medical aesthetics, and on developing and commercializing tissue repair products for orthobiologics, and advanced wound care markets. Our products are based on our rhCollagen (recombinant human collagen) that is produced with CollPlant’s proprietary plant based genetic engineering technology.
Our products address indications for the diverse fields of organ and tissue repair, and are ushering in a new era in regenerative medicine. Our flagship rhCollagen BioInk product line is ideal for 3D bioprinting of tissues and organs. We recently entered into a licensing agreement with United Therapeutics, whereby United Therapeutics is using CollPlant’s BioInks in the manufacture of 3D bioprinted lungs for transplant in humans. CollPlant’s unique Vergenix line of rhCollagen products includes a soft tissue repair matrix for treating tendinopathy and a wound repair matrix to promote a rapid optimal healing of acute and chronic wounds.
For more information about CollPlant, visit http://www.collplant.com
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